Q4 2025 Neurocrine Biosciences Inc Earnings Call

February 11, 2026

Speaker #2: Hello and welcome, everyone, joining today's Neurocrine Biosciences Q4 and FY 2025 earnings call. At this time, all participants are in a listen-only mode. Later, you will have the opportunity to ask questions.

Operator: Hello and welcome, everyone joining today's Neurocrine Biosciences Fourth Quarter and Fiscal Year 2025 Earnings Call. At this time, all participants are in a listen-only mode. Later, you will have the opportunity to ask questions during the question-and-answer session. To register to ask a question at any time, please press star one on your telephone keypad. Please note, this call is being recorded. We are standing by if you should need any assistance. It is now my pleasure to turn the meeting over to Todd Tushla, Vice President of Investor Relations. Please go ahead.

Speaker #2: During the question-and-answer session, to register to ask a question at any time, please press star 1 on your telephone keypad. Please note this call is being recorded.

Speaker #2: We are standing by if you should need any assistance. And it is now my pleasure to turn the meeting over to Todd Tushla, Vice President of Investor Relations.

Speaker #2: Please go ahead. Happy Wednesday to everyone, and welcome to Neurocrine Biosciences' Q4 and 2025 year-end earnings call. With me today are Kyle Gano, Chief Executive Officer; Matt Abernethy, Chief Financial Officer; Eric Benevich, Chief Commercial Officer; Sanjay Keswani, Chief Medical Officer; and for the first time, we are very pleased to be joined by Samir Siddhanti, Vice President of Strategy and Corporate Development.

Todd Tushla: Happy Wednesday to everyone, and welcome to Neurocrine Biosciences' Fourth Quarter and 2025 Year-End Earnings Call. With me today are Kyle Gano, Chief Executive Officer; Matt Abernethy, Chief Financial Officer; Eric Benevich, Chief Commercial Officer; Sanjay Keswani, Chief Medical Officer; and, for the first time, we are very pleased to be joined by Samir Sadanti, Vice President of Strategy and Corporate Development. During today's call, we will be making forward-looking statements. These statements are subject to certain risks and uncertainties, and our actual results may differ materially. I encourage you to review the risk factors discussed in our latest SEC filings. After prepared remarks, we'll be happy to address any questions. With that, Kyle, take it away.

Speaker #2: During today's call, we will be making forward-looking statements. These statements are subject to certain risks and uncertainties, and our actual results may differ materially.

Speaker #2: I encourage you to review the risk factors discussed in our latest SEC filings. After prepared remarks, we'll be happy to address any questions. With that, Kyle, take it away.

Speaker #3: Thanks, Todd. Good afternoon, everyone. A hallmark of a healthy company is the strength of the foundation beneath it. As Neurocrine enters 2026, our foundation is stronger than at any point in our more than 30-year history, and it continues to strengthen.

Kyle Gano: Thanks, Todd. Good afternoon, everyone. A hallmark of a healthy company is the strength of the foundation beneath it. As Neurocrine enters 2026, our foundation is stronger than at any point in our more than 30-year history, and it continues to strengthen. With growing enterprise-wide momentum and strategic balanced diversification, Neurocrine has entered a new era of meaningful growth led by our first and best-in-class commercial brands. INGREZZA performance continues to impress. Strategic investments in access and sales force expansion drove a record year for both new and total prescriptions. This momentum carries us into 2026 where, despite 9 years post-launch, we expect double-digit volume-driven growth supported by continued demand from the roughly 9 out of 10 TD or HD chorea patients not currently taking a VMAT2 inhibitor. Like INGREZZA, CRENESSITY's launch has also been exceptionally strong.

Speaker #3: With growing enterprise-wide momentum and strategic balanced diversification, Neurocrine has entered a new era of meaningful growth led by our first and best-in-class commercial brands.

Speaker #3: Ingresa performance continues to impress. Strategic investments in access and Salesforce expansion drove a record year for both new and total prescriptions. This momentum carries us into 2026, where, despite nine years post-launch, we expect double-digit, volume-driven growth supported by continued demand from the roughly 9 out of 10 TD or HD Korea patients not currently taking a VMAT2 inhibitor.

Speaker #3: Like Ingresa, Chronicity's launch has also been exceptionally strong. By the end of the fourth quarter, our first full commercial year after its approval in December 2024, prescriptions covered over 10% of the classic congenital adrenal hyperplasia patient population.

Kyle Gano: By the end of Q4, our first full commercial year after its approval in December 2024, prescriptions covered over 10% of the classic congenital adrenal hyperplasia patient population, underscoring the tremendous unmet need. What a great start, and I'd like to thank our team for making this all possible. This strong early adoption across patients, caregivers, and prescribers reinforces our conviction that CRENESSITY will become Neurocrine's second blockbuster product. With an FDA-approved label supporting uncompromised efficacy, including an efficacious first dose with no requirement for titration, multiple formulations for pediatric and adult populations, and a favorable safety and tolerability profile, CRENESSITY is rapidly becoming the standard of care for patients with classic CAH. This profile mirrors the attributes that supported the success of INGREZZA and underscores our confidence in CRENESSITY's impact for patients and Neurocrine moving forward.

Speaker #3: What a great start, and I'd like to thank our team for making this all possible. This strong early adoption across patients, caregivers, and prescribers reinforces our conviction that Chronicity will become Neurocrine's second blockbuster product.

Speaker #3: With an FDA-approved label supporting uncompromised efficacy—including an efficacious first dose with no requirement for titration—multiple formulations for pediatric and adult populations, and a favorable safety and tolerability profile, Chronicity is rapidly becoming the standard of care for patients with classic CH.

Speaker #3: This profile mirrors the attributes that supported the success of Ingrezza and underscores our confidence in Chronicity's impact for patients and Neurocrine moving forward. Turning to research and development, at our December R&D Day, we outlined three strategic pillars.

Kyle Gano: Turning to research and development, at our December R&D Day, we outlined three strategic pillars. First, we aim to lead the VMAT2 category by leveraging our deep INGREZZA experience in advancing next-generation VMAT2 inhibitors. By way of background, INGREZZA was the first approved treatment for tardive dyskinesia, and Neurocrine paved the path for the development of new medicines in this space. Our nearly 20-year history provides a durable foundation for category leadership. This starts with NBI 890, which recently entered into phase 2 in tardive dyskinesia, and with NBI 675, which is following close behind. Both of these products have the potential for long-acting injectable formulations. Second, we are delivering on the promise of CRF through a two-pronged approach, advancing next-generation CRF1 antagonists such as NBI-1435 and CAH, and expanding the platform with CRF2 agonists starting with NBI-2118 into adjacent areas, including metabolic diseases such as obesity.

Speaker #3: First, we aim to lead the VMAT2 category by leveraging our deep Ingresa experience in advancing next-generation VMAT2 inhibitors. By way of background, Ingresa was the first approved treatment for tardive dyskinesia and Neurocrine paved the path for the development of new medicines in this space.

Speaker #3: Our nearly 20-year history provides a durable foundation for category leadership. This starts with NBI-890, which recently entered into Phase 2 in tardive dyskinesia, and with NBI-675, which is following close behind.

Speaker #3: Both of these products have the potential for long-acting injectable formulations. Second, we are delivering on the promise of CRF through a two-pronged approach: advancing next-generation CRF1 antagonists, such as NBIP-1435 and CH, and expanding the platform with CRF2 agonists starting with NBIP-2118 and two adjacent areas, including metabolic diseases such as obesity.

Speaker #3: For more than 30 years, Neurocrine has been a pioneer in CRF biology, and this experience uniquely positions us to evolve and expand what CRF-based therapies can deliver.

Kyle Gano: For more than 30 years, Neurocrine has been a pioneer in CRF biology, and this experience uniquely positions us to evolve and expand what CRF-based therapies can deliver. Third, we are maximizing evolving the pipeline, which is stronger than ever. This is led by our late-stage, industry-leading neuropsychiatry portfolio, including two phase 3 programs: osavampator in major depressive disorder and direlotide in schizophrenia. Like INGREZZA and CRENESSITY before them, both represent potential first and best-in-class medicines. We expect top-line data from the osavampator studies and the first of two direlotide studies in 2027, which is shaping up to be the most data-rich year in Neurocrine's history. In 2025, we achieved our phase 1 through phase 3 objectives for the first time, making it the most productive clinical year in our history.

Speaker #3: Third, we are maximizing and evolving the pipeline, which is stronger than ever. This has been led by our late-stage, industry-leading neuropsychiatry portfolio, including two Phase 3 programs.

Speaker #3: Osivampator, a major depressive disorder, and direct leading in schizophrenia. Like Ingresa and Chronicity before them, both represent potential first and best-in-class medicines. We expect top-line data from the Osivampator studies in the first of two direct leading studies in 2027, which is shaping up to be the most data-rich year in Neurocrine's history.

Speaker #3: In 2025, we achieved our phase one through phase three objectives for the first time, making it the most productive clinical year in our history.

Speaker #3: We also have a clear line of sight to repeating this level of performance in 2026, accelerating us towards our goal of delivering one new medicine every two years at steady state.

Kyle Gano: We also have a clear line of sight to repeating this level of performance in 2026, accelerating us towards our goal of delivering one new medicine every two years at steady state. As I said from the outset, we enter 2026 with the strongest foundation in Neurocrine's history. It is incumbent upon me, our leadership team, and the entire organization to continue executing and delivering for patients and shareholders. We appreciate your support, and with that, I'll turn the call over to Matt.

Speaker #3: As I said from the outset, we enter 2026 with the strongest foundation in Neurocrine's history. It is a company upon me, our leadership team, and the entire organization to continue executing and delivering for patients and shareholders.

Speaker #3: We appreciate your support, and with that, I'll turn the call over to

Speaker #3: Matt: Thank you, Kyle, and good

Matt Abernethy: Thank you, Kyle, and good afternoon, everyone. 2025 was a noteworthy year for Neurocrine, as total product sales grew to more than $2.8 billion, representing 22% year-over-year growth. This performance reflects continued strength and durability from INGREZZA and the successful initial launch of CRENESSITY. Together, these products form the foundation of our growth and generate durable cash flows that support long-term shareholder value creation. INGREZZA generated just over $2.5 billion in revenue, up 9% year-over-year, driven by double-digit volume growth, partially offset by pricing concessions associated with formulary access investments to support long-term growth. Fourth quarter performance was in line with expectations outlined on our Q3 call. New prescriptions remain near record levels achieved in Q3, a strong result given the ongoing sales force expansion. Looking ahead, we are guiding to INGREZZA sales in the range of $2.7 to $2.8 billion in 2026, representing approximately 10% growth.

Speaker #2: Afternoon, everyone. 2025 was a noteworthy year for Neurocrine, as total product sales grew to more than $2.8 billion, representing 22% year-over-year growth.

Speaker #2: This performance reflects continued strength and durability from INGREZZA, and the successful initial launch of ChroniCITy. Together, these products form the foundation of our growth and generate durable cash flows that support long-term shareholder value creation.

Speaker #2: Ingresa generated just over $2.5 billion in revenue, up 9% year over year, driven by double-digit volume growth, partially offset by pricing concessions associated with formulary access investments to support long-term growth.

Speaker #2: Fourth quarter performance was in line with expectations, outlined on our Q3 call. New prescriptions remain near record levels achieved in Q3—a strong result, given the ongoing Salesforce expansion.

Speaker #2: Looking ahead, we are guiding to Ingresa's sales in the range of 2.7 to 2.8 billion dollars in 2026, representing approximately 10% growth. This outlook reflects continued double-digit volume growth, including contributions from the expanded Salesforce in the second half of the year, partially offset by price declines tied to formulary access improvements implemented in 2025.

Matt Abernethy: This outlook reflects continued double-digit volume growth, including contributions from the expanded Salesforce in the second half of the year, partially offset by price declines tied to formulary access improvements implemented in 2025. Overall, we expect net pricing in 2026 to be relatively consistent with levels exiting 2025. INGREZZA enters the year with strong NRX momentum, broad access, and an expanded commercial team ready to execute. For CRENESSITY, we exited 2025 with over $300 million in net product sales and approximately 10% of addressable patients being prescribed CRENESSITY. As a first-in-disease launch, quarter-over-quarter enrollment form activity can be variable, but what gives us confidence is the number of patients on therapy, refill behavior, and the speed of reimbursement. Feedback remains extremely positive, and our first year on the market exceeded both internal and external expectations.

Speaker #2: Overall, we expect net pricing in 2026 to be relatively consistent, with levels exiting 2025. Ingresa enters the year with strong NRX momentum, broad access, and an expanded commercial team, ready to execute.

Speaker #2: For Chronicity, we exited 2025 with over $300 million in net product sales and approximately 10% of addressable patients being prescribed Chronicity. As a first-in-disease launch, quarter-to-quarter enrollment form activity can be variable, but what gives us confidence is the number of patients on therapy, refill behavior, and the speed of reimbursement.

Speaker #2: Feedback remains extremely positive, and our first year on the market exceeded both internal and external expectations. Given that Chronicity is the first product approved for classic CAH in more than 70 years, with much still to learn around market dynamics, we are not providing specific sales guidance for 2026.

Matt Abernethy: Given that CRENESSITY is the first product approved for classic CAH in more than 70 years, with much still to learn around market dynamics, we are not providing specific sales guidance for 2026. Later in the call, Eric will discuss the initiatives underway to continue developing this attractive market. Turning to the financials, our cash position increased by approximately $700 million from $1.8 billion at the end of 2024 to $2.5 billion at the end of 2025, reflecting strong operating performance and a healthy balance sheet. While maximizing near-term profitability is not our primary objective, we remain highly profitable, delivering approximately 30% non-GAAP operating margin or roughly $850 million of non-GAAP operating income for 2025, including $83 million of R&D milestones and IP R&D expense. In 2026, we expect another strong year of non-GAAP operating income driven by increased product sales, partially offset by investments across SG&A and R&D.

Speaker #2: Later in the call, Eric will discuss the initiatives underway to continue developing this attractive market. Turning to the financials, our cash position increased by approximately $700 million, from $1.8 billion at the end of 2024 to $2.5 billion at the end of 2025, reflecting strong operating performance and a healthy balance sheet.

Speaker #2: While maximizing near-term profitability is not our primary objective, we remain highly profitable, delivering approximately 30% non-GAAP operating margin, or roughly $850 million of non-GAAP operating income for 2025, including $83 million of R&D milestones and IP R&D expense.

Speaker #2: In 2026, we expect another strong year of non-GAAP operating income, driven by increased product sales, partially offset by investments across SG&A and R&D. These investments align with our top capital allocation priorities of driving revenue growth and advancing our pipeline.

Matt Abernethy: These investments align with our top capital allocation priorities of driving revenue growth and advancing our pipeline. SG&A growth year-over-year primarily reflects investments related to our 2026 Salesforce expansion, which we expect to be completed by the end of the first quarter. At the midpoint of our guidance range, GAAP SG&A is expected to be in the low 40% of sales for 2026. R&D expense growth reflects a full year of investment in our phase 3 programs for osavampator and direlotide, with data expected in 2027, as well as the initiation of multiple phase 2 and phase 1 programs, including obesity. Overall, we expect GAAP R&D expense, excluding approximately $25 million in milestones, to be in the mid-30% of sales range, consistent with our prior commentary.

Speaker #2: SG&A growth year over year primarily reflects investments related to our 2026 Salesforce expansion, which we expect to be completed by the end of the first quarter.

Speaker #2: At the midpoint of our guidance range, GAAP SG&A is expected to be in the low 40% of sales for 2026. R&D expense growth reflects a full year of investment in our phase three programs for Osivampator and direct leading, with data expected in 2027.

Speaker #2: As well as the initiation of multiple phase two and phase one programs, including obesity. Overall, we expect GAAP R&D expense excluding approximately 25 million dollars of milestones to be in the mid-30% of sales range, consistent with our prior commentary.

Speaker #2: Overall, 2026 is shaping up to be another important year for Neurocrine as we continue to grow Ingresa and Chronicity while advancing our pipeline. We enter the year with strong momentum and are well positioned for continued growth.

Matt Abernethy: Overall, 2026 is shaping up to be another important year for Neurocrine as we continue to grow INGREZZA and CRENESSITY while advancing our pipeline. We enter the year with strong momentum and are well-positioned for continued growth. With that, I'll turn the call over to Eric Benevich, our Chief Commercial Officer. Eric.

Speaker #2: With that, I'll turn the call over to Eric Benevich, our Chief Commercial Officer. Eric.

Speaker #4: Thanks, Matt. I'm very proud of our team's performance last year across both Chronicity and Ingresa. And I'm equally enthusiastic about the significant opportunity ahead for both brands.

Eric Benevich: Thanks, Matt. I'm very proud of our team's performance last year across both CRENESSITY and INGREZZA, and I'm equally enthusiastic about the significant opportunity ahead for both brands. Matt covered the financial highlights, so I'll add additional color and highlight key focus areas to drive continued growth for both brands. For the CRENESSITY launch, you've heard us say, "So far, so great." And 2025 certainly lived up to that mantra, with over $300 million of net sales in the first full year on the market. Throughout 2025, we saw strong demand across pediatric and adult patients and across both genders, with prescriptions now trending towards a majority of pediatric patients and female patients on therapy. Importantly, while new patient starts may vary from week to week and quarter to quarter, once a patient initiates treatment with CRENESSITY, they tend to stay on CRENESSITY.

Speaker #4: Matt covered the financial highlights, so I'll add additional color and highlight key focus areas to drive continued growth for both brands. For the Chronicity launch, you've heard us say: so far, so great.

Speaker #4: And 2025 certainly lived up to that mantra, with over 300 million of net sales in the first full year on the market. Throughout 2025, we saw strong demand across pediatric and adult patients and across both genders, with prescriptions now trending towards a majority of pediatric patients and female patients on therapy.

Speaker #4: Importantly, while new patient starts may vary from week to week and quarter to quarter, once a patient initiates treatment with Chronicity, they tend to stay on Chronicity.

Speaker #4: This real-world experience is consistent with our experience in the open-label extension studies. As we've said from the outset, as a first-in-disease medicine, Chronicity is a learning launch.

Eric Benevich: This real-world experience is consistent with our experience in the open-label extension studies. As we've said from the outset, as a first-in-disease medicine, CRENESSITY is a learning launch, very much aligned with our experience with INGREZZA in TD. In fact, the parallels between the two launches are remarkably similar. Both INGREZZA and CRENESSITY are first-in-disease therapies for conditions that previously lacked specifically FDA-approved treatment options, and both achieved approximately $300 million in sales in their first 12 months. Being a first-in-disease launch, we still have much to learn about the patient population, the prescriber base, and potential seasonal dynamics. And similar to INGREZZA, while we're not providing specific annual guidance in year two, we remain highly confident that CRENESSITY will be Neurocrine's second blockbuster medicine as we establish it, together with replacement glucocorticoids, as the standard of care treatment for patients with classic congenital adrenal hyperplasia.

Speaker #4: Very much aligned with our experience with Ingrezza and TD. In fact, the parallels between the two launches are remarkably similar. Both Ingrezza and Chronicity are first-in-disease therapies for conditions that previously lacked specifically FDA-approved treatment options, and both achieved approximately $300 million in sales in their first 12 months.

Speaker #4: Being a first-in-disease launch, we still have much to learn about the patient population, the prescriber base, and potential seasonal dynamics. And similar to INGREZZA, while we're not providing specific annual guidance in year two, we remain highly confident that Chronicity will be Neurocrine's second blockbuster medicine as we establish it—together with replacement glucocorticoids—as the standard of care treatment for patients with classic congenital adrenal hyperplasia.

Speaker #4: As we enter Chronicity's second full year on the market, the natural question is, so what's next? As I noted this time last year, long-term success for Chronicity will be driven by our ability to reach, educate, and activate the CAH community on this breakthrough medicine.

Eric Benevich: As we enter CRENESSITY's second full year on the market, the natural question is, "So what's next?" As I noted this time last year, long-term success at CRENESSITY will be driven by our ability to reach, educate, and activate the CAH community on this breakthrough medicine. To date, more than 1,000 prescribers have written a prescription for CRENESSITY, yet roughly two-thirds have treated only one patient so far, underscoring both the progress we've made and the opportunity ahead. To support continued growth, we're focused on several key priorities in 2026. As previously announced, we're expanding the CRENESSITY sales force with new representatives hitting the field in April. This is a rare disease team, so the overall FTE numbers are still small. However, this expansion will allow us to go deeper within the existing endocrinology HCP base and allow us to expand our reach into additional potential prescribers.

Speaker #4: To date, more than 1,000 prescribers have written a prescription for Chronicity, yet roughly two-thirds have treated only one patient so far. This underscores both the progress we've made and the opportunity ahead.

Speaker #4: The support continued growth, we're focused on several key priorities in 2026. As previously announced, we're expanding the Chronicity Salesforce with new representatives hitting the field in April.

Speaker #4: This is a rare disease team, so the overall FTE numbers are still small. However, this expansion will allow us to go deeper within the existing endocrinology HCP base and allow us to expand our reach into additional potential prescribers.

Speaker #4: While endocrinologists remain central, we've learned some classic CAH patients are managed outside of endocrinology, by primary care providers or OB/GYNs. We're excited to leverage AI and other technology tools to help identify and engage providers likely to be caring for classic CAH patients.

Eric Benevich: While endocrinologists remain central, we've learned some classic CAH patients are managed outside of endocrinology by primary care providers or OB-GYNs. We're excited to leverage AI and other technology tools to help identify and engage providers likely to be caring for classic CAH patients. We're also continuing to invest in medical education to improve the community's understanding of CAH, the limitations of GC monotherapy, and reinforce CRENESSITY's compelling product profile. It remains the first and only new CAH-specific treatment in 70 years. As a potent and selective CRF1 antagonist, CRENESSITY targets the source of dysregulation in CAH and directly prevents the surge of excess ACTH from the pituitary to restore downstream androgen control and enable physiologic steroid dosing.

Speaker #4: We're also continuing to invest in medical education to improve the community's understanding of CAH, the limitations of GC monotherapy, and reinforce Chronicity's compelling product profile.

Speaker #4: It remains the first and only new CAH-specific treatment in 70 years. As a potent and selective CRF1 antagonist, Chronicity targets the source of dysregulation in CAH and directly prevents the surge of excess ACTH from the pituitary to restore downstream androgen control and enable physiologic steroid dosing.

Speaker #4: Furthermore, Chronicity has the largest data set in adults and children with classic CAH, which includes greater than 450 patient-years of clinical trial exposure and greater than 550 patient-years of real-world exposure.

Eric Benevich: Furthermore, CRENESSITY has the largest dataset in adults and children with classic CAH, which includes greater than 450 patient years of clinical trial exposure and greater than 550 patient years of real-world exposure. With a favorable long-term safety profile, robust efficacy, and broad labeling, it's clear why uptake has been so strong after only one year on the market. In fact, we estimate that we've gotten approximately 10% of the classic CAH population on therapy in the first year of availability. This is an important milestone for us. We believe, as the word continues to spread in the CAH community, as the endocrinology prescriber base expands, and as they share their real-world clinical experiences, we'll see a continued peer-to-peer effect that will deepen disease understanding and drive broader adoption.

Speaker #4: With a favorable long-term safety profile, robust efficacy, and broad labeling, it's clear why uptake has been so strong after only one year on the market.

Speaker #4: In fact, we estimate that we've gotten approximately 10% of the classic CAH population on therapy in the first year of availability. This is an important milestone for us.

Speaker #4: We believe as the word continues to spread in the CAH community, as the endocrinology prescriber base expands, and as they share their real-world clinical experiences, we'll see a continued peer-to-peer effect that will deepen disease understanding and drive broader adoption.

Speaker #4: Now, turning to Ingresa, we had a record number of new patient starts and a record number of total patients on therapy in 2025. Today, we estimate only about 10% of the prevalent TD population is currently taking a VMAT2 inhibitor.

Eric Benevich: Now, turning to INGREZZA, we had a record number of new patient starts and a record number of total patients on therapy in 2025. Today, we estimate only about 10% of the prevalent TD population is currently taking a VMAT2 inhibitor. Even nine years since our launch, there remains a substantial opportunity to grow the class, grow our market share, and help more patients start and stay on therapy. With double-digit growth momentum, strong formulary access, and an expanded and reorganized sales force set to hit the field in Q2, a class-leading and differentiated product profile, and 12 more years of remaining exclusivity, INGREZZA is well-poised to help many, many more TD and HD patients. So with that, I'll turn the call over to my colleague, Dr. Sanjay Keswani, to share our pipeline progress.

Speaker #4: Even nine years since our launch, there remains a substantial opportunity to grow the class, grow our market share, and help more patients start and stay on therapy.

Speaker #4: With double-digit growth momentum, strong formulary access, and an expanded and reorganized Salesforce set to hit the field in Q2, a class-leading and differentiated product profile, and 12 more years of remaining exclusivity, Ingresa is well poised to help many more TD and HC patients.

Speaker #4: So with that, I'll turn the call over to my colleague, Dr. Sanjay Keswani, to share our pipeline progress.

Speaker #2: Thanks, Eric, and good afternoon, everyone. In keeping with this year's focus on momentum and strategic diversification, our clinical organization will enroll in advance more studies than at any point in Neurocrine's history.

Sanjay Keswani: Thanks, Eric, and good afternoon, everyone. In keeping with this year's focus on momentum and strategic diversification, our clinical organization will enroll and advance more studies than at any point in Neurocrine's history. While most of my future earnings remarks will center on enrollment progress and study initiations, today I'll highlight recently disclosed data for our two commercial assets, INGREZZA and CRENESSITY. An optimal way to compare therapies is through head-to-head studies. With that in mind, we recently published first-of-its-kind head-to-head data comparing INGREZZA and AUSTEDO XR at the 64th annual meeting of the American College of Neuropharmacology. PET imaging results confirmed what we've long believed: not all VMAT2 inhibitors are equal. In this study, INGREZZA demonstrated a nearly twofold higher VMAT2 target occupancy compared with therapeutic doses of AUSTEDO XR, an important finding that indicates INGREZZA's superior efficacy in treating tardive dyskinesia.

Speaker #2: While most of my future earnings remarks will center on enrollment progress and study initiations, today I'll highlight recently disclosed data for our two commercial assets, INGREZZA and ChroniciTY.

Speaker #2: An optimal way to compare therapies is through head-to-head studies. With that in mind, we recently published first-of-its-kind head-to-head data comparing Ingresa and Osteedo XR at the 64th annual meeting of the Neuropharmacology.

Speaker #2: PET imaging results confirmed what we've long believed: not all VMAT2 inhibitors are equal. In this study, Ingresa demonstrated a nearly twofold higher VMAT2 target occupancy compared with therapeutic doses of Ongentys XR, an important finding that indicates Ingresa's superior efficacy in treating tardive dyskinesia.

Speaker #2: Turning to Chronicity, we recently shared data from our open-label extension study, while multiple analyses are still underway and will be presented at upcoming endocrinology meetings, including Endo 2026.

Sanjay Keswani: Turning to CRENESSITY, we recently shared data from our open-label extension study. While multiple analyses are still underway and will be presented at upcoming endocrinology meetings, including ENDO 2026, the main takeaway is clear: across both adult and pediatric CAH patients, CRENESSITY continues to show robust, sustained, clinically meaningful benefits through two years of treatment. We see durable reductions in excess ACTH and androgens, directly addressing the underlying pathophysiology of CAH and maintaining control over time. In pediatrics, CRENESSITY delivered sustained ACTH suppression while preserving normal physiological signaling, including the immune stress response. Hence, rates of adrenal insufficiency remained very low: zero in the pediatric double-blind study, and 1.6% in adults, identical between active and placebo patients. In a prepubertal subset, we also observed slowing of bone age advancement, translating to a predicted adult height increase of over two inches.

Speaker #2: The main takeaway is clear: across both adult and pediatric CAH patients, Chronicity continues to show robust, sustained, clinically meaningful benefits through two years of treatment.

Speaker #2: We see durable reductions in excess ACTH and androgens, directly addressing the underlying pathophysiology of CAH and maintaining control over time. In pediatrics, Chronicity delivered sustained ACTH suppression while preserving normal physiological signaling, including the immune stress response.

Speaker #2: Hence, rates of adrenal insufficiency remained very low—zero in the pediatric double-blind study and 1.6% in adults, identical between active and placebo patients. In a prepubertal subset, we also observed slowing of bone age advancement, translating to a predicted adult height increase of over two inches.

Speaker #2: In adults, approximately 70% of patients were brought into the physiological steroid range while maintaining androgen control, and about 40% of overweight or obese patients achieved at least 5% weight loss over two years, reflecting Chronicity's beneficial cardiometabolic effects.

Sanjay Keswani: In adults, approximately 70% of patients were brought into the physiological steroid range while maintaining androgen control, and about 40% of overweight or obese patients achieved at least 5% weight loss over 2 years, reflecting CRENESSITY's beneficial cardiometabolic effects. Safety and tolerability remain excellent, with approximately 80% retention at 2 years, no new safety signals, and over 35,000 patient weeks of exposure. Overall, these data reinforce CRENESSITY's strong differentiation across efficacy, safety, and tolerability, and support our conviction that it will continue to be the standard of care treatment for patients with classic congenital adrenal hyperplasia. Regarding our industry-leading neuropsychiatry programs, the late-stage Phase 3 studies for osavampator in major depressive disorder and direlotide in schizophrenia are enrolling well, and just last month, we initiated a Phase 2 study of NBI 890, our next-generation VMAT2 inhibitor for the treatment of tardive dyskinesia.

Speaker #2: Safety and tolerability remain excellent, with approximately 80% retention at two years, no new safety signals, and over 35,000 patient-weeks of exposure. Overall, these data reinforce Chronicity's strong differentiation across efficacy, safety, and tolerability, and support our conviction that it will continue to be the standard of care treatment for patients with classical congenital adrenal hyperplasia.

Speaker #2: Regarding our industry-leading neuropsychiatry programs, the late-stage Phase III studies for osivampator in major depressive disorder and direct Lydine in schizophrenia are enrolling well. And just last month, we initiated a Phase II study of NBI-890, our next-generation VMAT2 inhibitor for the treatment of tardive dyskinesia.

Speaker #2: All other studies in our portfolio are advancing as expected, and we look forward to keeping you apprised of our progress. With that, I'll hand the call back to Kyle.

Sanjay Keswani: All other studies in our portfolio are advancing as expected, and we look forward to keeping you apprised of our progress. With that, I'll hand the call back to Kyle.

Speaker #1: Thanks, Chloe. I think we can go ahead and take questions now.

[Company Representative] (Neurocrine Biosciences): Thanks, Chloe. I think we can go ahead and take questions now.

Kyle Gano: Thanks, Chloe. I think we can go ahead and take questions now.

Speaker #3: Absolutely. If you'd like to ask a question, press star 1 on your keypad. To leave the cue at any time, press star 2. Once again, that is star 1 to ask a question.

Operator: Absolutely. If you'd like to ask a question, press star one on your keypad. To leave the queue at any time, press star two. Once again, that is star one to ask a question. Thank you. Our first question comes from Paul Matteis with Stifel. Your line is open.

Speaker #3: Thank you. Our first question comes from Paul Matisse with Stifel. Your line is open.

Speaker #1: Hey, good afternoon. Congrats and thanks for taking my question. I appreciate that you're not guiding on Chronicity, but I was wondering if you could maybe give us either a window into the first six weeks of 2026 or just more broadly the number on the revenue side.

Paul Matteis: Hey, good afternoon. Congrats, and thanks for taking my question. I appreciate that you're not guiding on CRENESSITY, but I was wondering if you could maybe give us either a window into the first six weeks of 2026 or just more broadly the number on the revenue side, obviously way above consensus in Q4, but as we look at NRx, there's a slight decline from Q2 to Q3 and Q3 to Q4. Curious in your perspective on what you're seeing now and where you think this kind of patient add rate might plateau in, say, the near to midterm. Thank you.

Speaker #1: Obviously, way above consensus in 4Q, but as we look at Star Forms, there's a slight decline. From 2Q to 3Q and 3Q to 4Q, curious in your perspective on what you're seeing now and where you think this kind of patient ad rate might plateau in, say, the near to midterm.

Speaker #1: Thank you.

Speaker #4: Paul, so we're going to start giving weekly sales information out on the web. Just kidding. I mean, it's been a

Eric Benevich: Paul, so we're going to start giving weekly sales information out on the web. Just kidding. I mean, it's been a tremendous year for.

Speaker #4: Tremendous year for—love it. It's been a tremendous year.

Paul Matteis: Love it.

Speaker #1: it.

Eric Benevich: It's been a tremendous year for CRENESSITY, over $300 million in the first year. Congratulations to the team. We really look forward to year two being another strong, exciting year. We do anticipate meaningful, steady new patient additions every single quarter. That's going to lead to a very nice growth year. We still, of course, have a whole lot to learn associated with this launch. As you remember, with INGREZZA, it took us about four years to get to a guide, but we will be providing insight every quarter as it relates to net sales, demand, and overall reimbursement dynamics. I'd say looking around the table, we couldn't be more proud of the team and what's been accomplished this year and really feel good with how we're positioned for the years ahead.

Speaker #4: for Chronicity. Over 300 million in the first year, congratulations to the team. And we really look forward to year two being another strong exciting year.

Speaker #4: We do anticipate meaningful, steady new patient additions every single quarter. That's going to lead to a very nice growth year. We still, of course, have a whole lot to learn associated with this launch. As you remember, with Ingrezza, it took us about four years to get to a guide.

Speaker #4: But we will be providing insight every quarter as it relates to net sales, demand, and overall reimbursement dynamics, I'd say, looking around the table.

Speaker #4: We couldn't be more proud of the team and what's been accomplished this year. And really feel good with how we're positioned for the years ahead.

Speaker #1: Look forward to the weeklies.

Paul Matteis: Look forward to the weeklies.

Speaker #3: We'll take our next question from Corey Kasimov with Evercore ISI. Your line is open.

Operator: We'll take our next question from Corey Kasimov with Evercore ISI. Your line is open.

Speaker #3: open.

Speaker #1: Hey, good afternoon,

Kyle Gano: Hey, good afternoon, guys. Thanks for taking my question. Wanted to ask about that receptor occupancy poster from late January regarding INGREZZA versus AUSTEDO. Curious how you might use this information and what are the potential implications here with regard to your next-gen VMAT2 inhibitors. Thank you.

Cory Kasimov: Hey, good afternoon, guys. Thanks for taking my question. Wanted to ask about that receptor occupancy poster from late January regarding INGREZZA versus AUSTEDO. Curious how you might use this information and what are the potential implications here with regard to your next-gen VMAT2 inhibitors. Thank you.

Speaker #1: guys. Thanks for taking my question. Wanted to ask about that receptor occupancy poster from late January, regarding Ingresa versus Austeto. Curious how you might use this information and what are the potential implications here with regard to your next-gen VMAT2 inhibitors.

Speaker #1: Thank

Speaker #2: Yeah, so it's quite exciting, the data we showed, which is essentially a head-to-head PET study between Asteda XR and Ingresa. And as we articulated in our recent press release, we saw nearly double the target occupancy for Ingresa after one dose, and even when we measured at steady state versus Asteda XR.

Sanjay Keswani: Yeah, so we're quite excited by the data we showed, which is essentially a head-to-head PET study between AUSTEDO XR and INGREZZA. And as we articulated in our recent press release, we saw nearly double the target occupancy for INGREZZA after one dose versus AUSTEDO XR. And even when we measured at steady state concentrations, we still had a markedly superior advantage in terms of VMAT2 target engagement. We think this underlines the efficacy that we see in INGREZZA in the community of patients with tardive dyskinesia, as our belief is that the higher the rate of VMAT2 target occupancy, the greater the efficacy in terms of control of tardive dyskinesia. In terms of the second part of your question, we clearly have a lot of experience in terms of matching receptor occupancy with clinically efficacious doses. And we're utilizing that relationship with our two VMAT2 follow-ons.

Speaker #2: At those concentrations, we still had a markedly superior advantage in terms of VMAT2 target engagement. We think this underlines the efficacy that we see in Ingrezza in the community of patients with tardive dyskinesia.

Speaker #2: As our belief is that the higher the rate of VMAT2 target occupancy, the greater the efficacy in terms of control of tardive dyskinesia. In terms of the second part of your question, we clearly have a lot of experience in terms of matching receptor occupancy with clinically efficacious doses.

Speaker #2: And we're utilizing that relationship with our two VMAT2 follow-ons. Indeed, we started a Phase II study of our first follow-on in tardive dyskinesia quite

Sanjay Keswani: Indeed, we started a phase 2 study of our first follow-on in tardive dyskinesia quite recently.

Speaker #2: recently. Great.

Kyle Gano: Great. Thank you.

Cory Kasimov: Great. Thank you.

Speaker #1: Thank you.

Operator: We'll take our next question from Phil Nadeau with TD Cowen. Your line is open.

Speaker #3: our first question from or we'll take We'll take our next question from Phil Nadeau with TD Cowan. Your line is

Operator: We'll take our next question from Phil Nadeau with TD Cowen. Your line is open.

Speaker #3: open. Good afternoon.

Phil Nadeau: Good afternoon. Thanks for taking our questions, and congratulations on a productive year. We just wanted to follow up on Paul's question on patient dynamics with CRENESSITY. I think in your prepared remarks, you mentioned the possibility of seasonality in patient demand, and I think investors were all debating whether there could have been an early launch bolus to patient initiations. Appreciating that you still have a lot to learn. What have you learned about those two factors in patient dynamics, one in early launch bolus, and two, whether there's any seasonality as you go through the year? Thanks.

Speaker #5: Thanks for taking our questions, and congratulations on a productive year. We just wanted to follow up on Paul's question on patient dynamics with Chronicity.

Speaker #5: I think in your prepared remarks, you mentioned the possibility of seasonality in patient demand. And I think investors are all debating whether there could have been an early launch bolus to patient initiations, appreciating that you still have a lot to learn.

Speaker #5: What have you learned about those two factors in patient dynamics: one, in early launch bolus; and two, whether there's any seasonality as you go through the year?

Speaker #5: Thanks.

Speaker #4: Yeah,

Kyle Gano: Yeah, thanks, Phil. This is Kyle. Good question here on that. I think it's important to keep in mind that the similarities that Eric called out of his opening remarks here are quite true and accurate across the board. In terms of the first year of launch, we've gone through our first Q1 through Q4. As we've learned in most orphan diseases and launches, whether it was INGREZZA or looking at others, there's always ebbs and flows in enrollment forms. And in particular, early in launch, it's typically a function of frequency of office visits when patients initially hear about the opportunity for new medicine and physicians getting the word out. So I think it's too early to call whether or not there's any seasonality component. It takes a couple of quarters to draw those conclusions across multiple years.

Speaker #4: Thanks, Phil. This is Kyle. Good question here on that. I think it's important to keep in mind that the similarities that Eric called out in his opening remarks here are quite true and accurate across the board.

Speaker #4: In terms of the first year of launch, we've gone through our first Q1 through Q4. As we've launched, whether it was Ingrezza or looking at others, we've learned in most orphan diseases there's always ebbs and flows in enrollment forms.

Speaker #4: And in particular, early in launch, it's typically a function of frequency of office visits when patients initially hear about the opportunity for a new medicine.

Speaker #4: And physicians getting the word out. So, I think it's too early to call whether or not there's any seasonality component. It takes a couple of quarters to draw those conclusions.

Speaker #4: Across multiple years. And it took us a while to get to that level of confidence with Ingrezza. So I think it's prudent right now to collect that information and make a more sound decision about guidance, enrollment forms, things of that sort as we get a little bit further into launch.

Kyle Gano: It took us a while to get to that level of confidence with INGREZZA. So I think it's prudent right now to collect that information and make a more sound decision about guidance, enrollment forms, things of that sort as we get a little bit further in the launch. But rest assured, great feedback out there across all the stakeholders, prescribers, physicians, and even payers out there. So nothing out there is saying that we're anywhere but moving towards changing the standard of care and achieving blockbuster status like we've done with INGREZZA.

Speaker #4: But rest assured, great feedback out there across all the stakeholders—prescribers, physicians, and even payers out there. So nothing out there is saying that we're anywhere but moving towards changing the standard of care and achieving blockbuster status like we've done with—

Speaker #4: Ingresa. We'll take our next question from

Operator: We'll take our next question from Brian Abrahams with RBC Capital Markets. Your line is open.

Speaker #3: Your next question comes from Brian Abrams with RBC Capital Markets.

Speaker #5: Hey, guys. Thanks for taking my question. And my congrats as well on a very productive year. Question on the expense side: it seems like you're expecting a little bit of an uptick in R&D expenses for this year relative to 2025.

Sanjay Keswani: Hey, guys. Thanks for taking my question and my congrats as well on a very productive year. Question on the expense side. It seems like you're expecting a little bit of an uptick in R&D expenses for this year relative to 2025. Can you talk a little bit more about the components of that? How much of that is some of the earlier stage programs like obesity? And how quickly could some of those costs potentially roll off in 2027 once the two phase 3 is read out? Thanks.

Brian Abrahams: Hey, guys. Thanks for taking my question and my congrats as well on a very productive year. Question on the expense side. It seems like you're expecting a little bit of an uptick in R&D expenses for this year relative to 2025. Can you talk a little bit more about the components of that? How much of that is some of the earlier stage programs like obesity? And how quickly could some of those costs potentially roll off in 2027 once the two phase 3 is read out? Thanks.

Speaker #5: Can you talk a little bit more about the components of that? How much of that is some of the earlier stage programs, like obesity?

Speaker #5: And how quickly could some of those costs potentially roll off in 2027 once the two Phase 3s read out?

Speaker #5: Thanks. Yeah, thank you for

Eric Benevich: Yeah, thank you for the question. The cost increase is really on the heels of the phase 3 trials and pushing those forward for a full year this year in 2026. The obesity investment is actually quite minimal for 2026, but of course, is a really important program for us to be able to drive shareholder value creation, which we would expect some level of data in 2027. But from an expense, when do expenses roll off? We would anticipate for the major phase 3 programs, those will carry on through 2027 with a big chunk falling off in 2028.

Speaker #4: The cost increase is really on the heels of the Phase III trials and pushing those forward for a full year this year.

Speaker #4: In 2026, the obesity investment is actually quite minimal. For 2026, it is, of course, a really important program for us to be able to drive shareholder value creation, which we would expect some level of data in 2027.

Speaker #4: But from an expense window, expenses roll off. We would anticipate for the major Phase III programs, those will carry on through 2027, with a big chunk falling off in

Speaker #3: We'll move next to Tazeem Em Ahmad with Bank of America. Your line is open.

Operator: We'll move next to Tazeen Ahmad with Bank of America. Your line is open.

Speaker #3: open. Hi, guys.

Paul Choi: Hi, guys. Thanks for taking my question. I wanted to go back to CRENESSITY for a second. So I know it took, what is it, three or four years before you guys started giving guidance on INGREZZA. What kind of metrics did you need to collect in order to get confident in providing guidance? And do you have a sense of whether or not it would take that length of time before you get confident with CRENESSITY and providing sales guidance for that as well? Thanks.

Tazeen Ahmad: Hi, guys. Thanks for taking my question. I wanted to go back to CRENESSITY for a second. So I know it took, what is it, three or four years before you guys started giving guidance on INGREZZA. What kind of metrics did you need to collect in order to get confident in providing guidance? And do you have a sense of whether or not it would take that length of time before you get confident with CRENESSITY and providing sales guidance for that as well? Thanks.

Speaker #6: Thanks for taking my question. I wanted to go back to Chronicity for a second. So, I know it took, what is it, three or four years before you guys started giving guidance on Ingrezza.

Speaker #6: What kind of metrics did you need to collect in order to get confident in providing guidance? And do you have a sense of whether or not it would take that length of time before you get confident with Chronicity and providing sales guidance for that as well?

Speaker #4: Yeah, hi, Tazeem. Maybe I'll tackle the second question first. It may not take as long to get to a point where we feel comfortable giving guidance with Chronicity as it did with INGREZZA.

Eric Benevich: Yeah, hi, Tazeen. Maybe I'll tackle the second question first. It may not take as long to get to a point where we feel comfortable giving guidance with CRENESSITY as it did with INGREZZA. This is a rare disease. INGREZZA is not a rare disease, but it was at the time a rarely diagnosed disease. We have essentially a single prescriber base in endocrinology versus multiple different specialties in different sites of care and so on, which made getting a handle on INGREZZA a little bit more challenging early on. As I mentioned in my prepared remarks, both are first-in-disease therapies, both are breakthrough medicines. But as Kyle stated, we've gone through one cycle so far with CRENESSITY and classic CAH, and it has been a learning launch for us. There's a few factors that have been a little bit different than what we expected, but different in the positive.

Speaker #4: This is a rare disease. Ingrezza is not a rare disease, but it was at the time a rarely diagnosed disease. We have essentially a single prescriber base in endocrinology versus multiple different specialties in different sites of care, and so on, which made getting a handle on Ingrezza a little bit more challenging early on.

Speaker #4: As I mentioned in my prepared remarks, both our first-in-disease therapies, both our breakthrough medicines—but as Kyle stated, we've gone through one cycle so far with Chronicity and classic CAH, and it has been a learning launch for us.

Speaker #4: There are a few factors that have been a little bit different than what we expected, but different in a positive way. The adoption rate was greater than what we had expected coming into this launch, which is awesome.

Eric Benevich: The adoption rate was greater than what we had expected coming into this launch, which is awesome. Certainly, the reimbursement has been favorable, and we've been very pleased with the persistency that we've seen. When patients start treatment, they tend to stay on it. So as we get more experience in this community, in the CAH community, and as we learn more about how we're able to reach sort of beyond that first 10% of the population that I talked about, then I think we'll get to a point down the road where we feel more comfortable providing specific guidance. Let's not confuse not providing guidance with not expecting significant growth this year. Everything that we see from steady enrollments of new patients along with patients staying on therapy, everything points to there continuing to be strong growth.

Speaker #4: Certainly, the reimbursement has been favorable. And we've been very pleased with the persistency that we've seen when patients start treatment—they tend to stay on it.

Speaker #4: So, as we get more experience in this community, in the CAH community, and as we learn more about how we're able to reach sort of beyond that first 10% of the population that I talked about, then I think we'll get to a point down the road where we feel more comfortable providing specific—

Speaker #4: So, as we get more experience in this community—in the CAH community—and as we learn more about how we're able to reach sort of beyond that first 10% of the population that I talked about, then I think we'll get to a point down the road where we feel more comfortable providing specific guidance.

Speaker #5: Let's not confuse not providing guidance with not expecting significant growth this year. Everything that we see—from steady enrollments of new patients along with patients staying on therapy—everything points to there continuing to be strong growth.

Speaker #5: It's just a company decision that we made to not provide a guide here.

Eric Benevich: It's just a company decision that we made to not provide a guide here.

Speaker #3: We'll move next to Corinne Johnson with Goldman Sachs. Your line is open.

Operator: We'll move next to Corinne Jenkins with Goldman Sachs. Your line is open.

Speaker #6: Thanks and good afternoon. I guess beyond the pricing discussion, with respect to Ingresa and Austetta, which I guess is now better understood, how are you thinking about volume impact to Ingresa next year with Austetta becoming a negotiated product?

Paul Choi: Thanks and good afternoon. I guess beyond the pricing discussion with respect to INGREZZA and AUSTEDO, which I guess is now better understood, how are you thinking about volume impact to INGREZZA next year with AUSTEDO becoming a negotiated product? How do you think formularies are going to handle peer products in the context of maybe more relatively competitive pricing than we could have expected? Thanks.

Corinne Jenkins: Thanks and good afternoon. I guess beyond the pricing discussion with respect to INGREZZA and AUSTEDO, which I guess is now better understood, how are you thinking about volume impact to INGREZZA next year with AUSTEDO becoming a negotiated product? How do you think formularies are going to handle peer products in the context of maybe more relatively competitive pricing than we could have expected? Thanks.

Speaker #6: And how do you think formularies are going to handle peering products in the context of maybe more relatively competitive pricing than we could have expected?

Speaker #6: Thanks.

Speaker #4: Yeah,

Eric Benevich: Yeah, I mean, obviously, we've been thinking and preparing for the 2027 formulary year and the impact of deuterated tetrabenazine having an MFP negotiated price. But certainly, we're very focused on 2026 as we kind of prepare to go into that next phase. We're in a position now, and Kyle talked about it with his prepared remarks, of carrying a lot of momentum into 2026 in terms of our volume growth and new patient starts, having favorable coverage, especially in the Medicare formularies, and being able to leverage all of that as we enter into the formulary negotiations for 2027. So we feel good about our strategy for 2027. We believe we'll be able to maintain formulary coverage to enable continued growth.

Speaker #4: I mean, obviously, we've been thinking and preparing for the 2027 formulary year and the impact of deuterated tetrabenazine having an MFP-negotiated price. But certainly, we're very focused on 2026.

Speaker #4: As we kind of prepare to go into that next phase, we're in a position now—and Kyle talked about it with his prepared remarks—of carrying a lot of momentum into 2026 in terms of our volume growth and new patient starts, having favorable coverage especially in the Medicare formularies.

Speaker #4: And being able to leverage all of that as we enter into the formulary negotiations for 2027. So we feel good about our strategy for 2027.

Speaker #4: We believe we'll be able to maintain formulary coverage to enable continued growth. And this is a market that has been growing at a double-digit clip for the last several years, which is pretty amazing, especially for a category that's coming into year nine, year 10.

Eric Benevich: This is a market that has been growing at a double-digit clip for the last several years, which is pretty amazing, especially for a category that's coming into year nine, year ten. So we feel good about 2026, expect to have another really strong year for INGREZZA, and we feel good about our strategy for maintaining that growth in 2027 and beyond.

Speaker #4: So we feel good about 2026, expect to have another really strong year for Ingresa. And we feel good about our strategy for maintaining that growth in

Speaker #4: 2027 and beyond. And the

Kyle Gano: The only thing I would add to that, this is Kyle, by the way, is that on the 2026, we have our contracting done that we pulled through in 2025, so we expect that to be stable this year. No mid-year adds like we saw in 2025. So entering '26, we expect the net revenue per prescription to be roughly similar throughout the course of the year. So revenue growth should also track nicely volume growth this year. That's our expectation. So a strong year here like in 2025. We expect good double-digit volume growth and to increase our market share throughout the course of the year.

Speaker #5: other thing I would add to that, this is Kyle, by the way, is that on the 2026, we have our contracting done that we pulled through in 2025.

Speaker #5: So, we expect that to be stable this year—no mid-year adds like we saw in 2025. So, entering '26, we expect the net revenue per prescription to be roughly similar throughout the course of the year.

Speaker #5: So revenue growth should also track nicely volume growth this year. That's our expectation. So a strong year here like in 2025, we expect good double-digit volume growth and to increase our market share throughout the course of the year.

Speaker #3: We'll take our next question from Jay Olson with Oppenheimer. Your line is

Operator: We'll take our next question from Jay Olson with Oppenheimer. Your line is open.

Speaker #3: open.

Speaker #7: If you were to ask more about the. Oh,

Eric Benevich: Thank you for asking more about the.

Phil Nadeau: Oh, hey, guys. Congrats on all the progress, and thank you for taking our question. We're curious about the 569 study in Alzheimer's psychosis and any potential lessons learned from the Adept II study of Cobenfi, especially in terms of managing trial conduct across the study sites and any strategies you can use to mitigate operational risks for that study. Thank you.

Jay Olson: Oh, hey, guys. Congrats on all the progress, and thank you for taking our question. We're curious about the 569 study in Alzheimer's psychosis and any potential lessons learned from the Adept II study of Cobenfi, especially in terms of managing trial conduct across the study sites and any strategies you can use to mitigate operational risks for that study. Thank you.

Speaker #8: you for taking our question. We're curious about the 569 hey, guys. Congrats on all the progress. And thank study in Alzheimer's psychosis and any potential lessons learned from the ADEPT2 study of Cobenfi.

Speaker #8: Especially in terms of managing trial conduct across the study sites and any strategies you can use to mitigate operational risks for that study. Thank you.

Speaker #9: Yeah, we're watching the progress of Cobenfi and AD psychosis quite carefully. But just as an aside, psychiatry studies deserve specific attention. And we are fortunate to have a very experienced team who've successfully executed psychiatry studies.

Sanjay Keswani: Yeah, we're watching the progress of Cobenfy and AD psychosis quite carefully. But just as an aside, psychiatry studies deserve specific attention. We are fortunate to have a very experienced team who've successfully executed psychiatry studies. So for both our phase 3 studies, we spent a lot of time carefully selecting sites and ensuring that the patients enrolled in our studies are real patients rather than professional patients who may inflate a placebo response. And indeed, with respect to placebo mitigation, we have a multifold strategy with respect to design of the studies, 1:1 randomization, and keeping the study sites relatively small. So, for example, we only have 20 sites per phase 3 study for direlotide in our schizophrenia studies. And also a great deal of hands-on monitoring of sites and site investigators by our internal team.

Speaker #9: So for both our phase three studies, we spent a lot of time carefully selecting sites and ensuring that the patients enrolled in our studies are real patients rather than professional patients who may inflate a placebo response.

Speaker #9: And indeed, with respect to placebo, mitigation, we have a multifold strategy with respect to design of the studies. One-to-one randomization, keeping the study sites relatively small.

Speaker #9: So, for example, we only have 20 sites per Phase 3 study for direct leading in our schizophrenia studies. And also, a great deal of hands-on monitoring of sites and site investigators by our internal team.

Speaker #9: So, I think the BMS data were—invited some caution with respect to ensuring that we adequately monitor these sites. But we feel in a pretty good position in terms of doing that already.

Sanjay Keswani: So I think the BMS data have invited some caution with respect to ensuring that we adequately monitor these sites, but we feel in a pretty good position in terms of doing that already.

Speaker #3: We'll take our next question from Anupam Ramma with JP Morgan. Your line is open.

Operator: We'll take our next question from Anupam Rama with J.P. Morgan. Your line is open.

Anupam Rama: Hi, this is Joyce Ahn for Anupam. Thanks so much for taking our question. Could you discuss the feedback you've been getting from KOLs about your two-year CRENESSITY data, specifically as it relates to durability of benefit, and just how you see this data continuing to support and drive strong persistence of patients on drug? Thank you.

Speaker #6: Anupam. Thanks so much for taking our question. Could you discuss the feedback you've been Hi, this is Joyce on for getting from KOLs about your two-year chronicity data?

Speaker #6: Specifically, as it relates to durability of benefit and just how you see this data as continuing to support and drive strong persistence of patients on drug.

Speaker #6: Thank

Speaker #6: you. Yeah, so we've been getting a lot

Sanjay Keswani: Yeah, so we've been getting a lot of positive support from clinicians who have been prescribing CRENESSITY, as you say, for some time now. And we recently showed that 2-year data and, again, elicited a lot of positive feedback. I think what's important for these patients and often their parents is showing that androgens are reduced in a chronic fashion. And by doing so, reducing doses of glucocorticoids to "physiological levels." And that's a huge deal for this patient population who are essentially plagued by the side effects of chronic glucocorticoid use. So in our 2-year dataset, we saw reductions in weight for those individuals who are obese, improved insulin tolerance. And with respect to androgen suppression, we also saw attenuation of bone age advancement. And that's a big deal for these patients.

Speaker #9: of positive support from clinicians who have been prescribing chronicity, as you say, for some time now. And we recently showed that two-year data and again elicited a lot of positive feedback.

Speaker #9: I think what's important for these patients and often their parents is showing that androgen are reduced in a chronic fashion. And by doing so, reducing doses of glucocorticoids to "physiological levels." And that's a huge deal for this patient population, who are essentially plagued by the side effects of chronic glucocorticoid use.

Speaker #9: So, in our two-year data set, we saw reductions in weight for those individuals who were obese, improved insulin tolerance, and, with respect to androgen suppression, we also saw attenuation of bone age advancement.

Speaker #9: And that's a big deal for these patients—and again, their parents—because often these individuals have precocious puberty and don't attain their potential with respect to adult height.

Sanjay Keswani: And again, their parents, because often these individuals have precocious puberty and don't attain the potential with respect to adult height. So really pleased to see that data and also the positive impacts on the community. Lastly, I'll say that the drug is actually really well tolerated, very important, particularly in a pediatric population. So no surprises at all despite collecting over 35,000 patient weeks of exposure. Of note, we do preserve the vasopressin-induced ACTH stimulus. I mentioned that because adrenal insufficiency is always a worry, particularly as you reduce glucocorticoids. And we're very happy with that adrenal insufficiency data. Indeed, no cases in the pediatric population and an active versus placebo rate that was equivalent in the adult population. So hopefully, that addressed your question.

Speaker #9: So really pleased to see that data and also the positive impacts on the community. Lastly, I'll say that the drug is actually really well tolerated.

Speaker #9: Very important, particularly in a pediatric population. So no surprises at all, despite collecting over 35,000 patient weeks of exposure. Of note, we do preserve the vasopressin-induced ACTH stimulus.

Speaker #9: I mentioned that because adrenal insufficiency is always a worry. Particularly as you reduce glucocorticoids. And we're very happy with that adrenal insufficiency data indeed no cases in the pediatric population.

Speaker #9: And an active versus placebo rate that was equivalent in the adult population. So hopefully that addressed your

Speaker #9: Question. Yeah, this is Kyle, maybe.

Kyle Gano: Yeah, this is Kyle. Maybe just add two quick comments on there. I think the pieces that are really important is if you think about safety and tolerability, the open-label extension, 90% of subjects rolled over and then 80% out to two years. Just an amazing safety and tolerability profile. And CAH, although you could say this about many disease states, more so than ever for CAH, efficacy gets your foot in the door, but safety and tolerability wins the day. And I think the other piece is on the efficacy that we see at two years. It really describes the benefits of long-term treatment. You can really bend the course of the disease in terms of progression. The earlier you treat, the younger you are, and the longer you stay on treatment. So all good things to think about when we continue to accumulate this longer-term data.

Speaker #5: Just to add two quick comments on there. I think the pieces that are really important are, if you think about safety and tolerability, in the open-label extension, 90% of subjects rolled over.

Speaker #5: And then 80% out to two years. Just an amazing safety and tolerability profile. And CH, although you could say this about many disease states—more so than ever for CH—efficacy gets your foot in the door, but safety and tolerability wins the day.

Speaker #5: And I think the other piece is, on the efficacy that we see at two years, it really describes the benefits of long-term treatment. You can really bend the course of the disease, in terms of progression, the earlier you treat, the younger you are, and the longer you stay on treatment.

Speaker #5: So, all good things to think about when we continue to accumulate this longer-term data.

Speaker #3: We'll move next to Mohit Bansal with Wells Fargo. Your line is

Speaker #3: We'll move next to Mohit Bansal with Wells Fargo. Your line is open. Great.

Operator: We'll move next to Mohit Bansal with Wells Fargo. Your line is open.

Mohit Bansal: Great. Thank you very much for taking my question. So one is regarding the expenses on the SG&A side. It seems like the sales and marketing increase is more than what we have seen last year. Can you just help us understand, is it more towards CRENESSITY or INGREZZA? And then would also love to understand how you're thinking about INGREZZA given that you are guiding for a 10% growth, which is higher than last year. So do you expect volumes to continue to grow at the rate of last year, or just you're not seeing price decline this year? So that's probably what is driving it. Thank you.

Speaker #10: Thank you very much for taking my question. So one is regarding the expenses on the SGNA side. It seems like the sales and marketing increase is more than what we have seen last year.

Speaker #10: Can you just help us understand, is it more towards chronicity or Ingrezza? And then, would also love to understand how you're thinking about Ingrezza, given that you are guiding for 10% growth, which is higher than last year.

Speaker #10: So do you expect volumes to continue to grow at the rate of last year? Or is it just like you're not doing price decline this year?

Speaker #10: So that's probably what is driving it. Thank

Speaker #10: you.

Speaker #2: So SG&A expenses—really, the Salesforce expansion that we mentioned on the last call is a significant part of that. And we also have other ancillary initiatives surrounding chronicity as well as Ingrezza.

Eric Benevich: So SG&A expense is really the sales force expansion that we mentioned on the last call is a significant part of that. And we also have other ancillary initiatives surrounding CRENESSITY as well as INGREZZA to ultimately drive sales. But this coming year, we do expect double or this year, we expect double-digit growth, as we've said. That's partially offset by price, call it -4%, based upon the pricing that we the contracting that we had entered into in the first half of last year. So you're talking about volume growth at the midpoint of our guidance range for INGREZZA to be in the mid-teens. So we feel really good with where the team is positioned. And of course, with the sales force expansion going to be in place at the end of Q1, we'd expect to see more benefit in the second half of the year.

Speaker #2: To ultimately drive sales. But this coming year, we do expect double or this year we expect double-digit growth as we've said. That's partially offset by price, call it negative 4% based upon the pricing that we the contracting that we had entered into in the first half of last year.

Speaker #2: So, you're talking about volume growth at the midpoint of our guidance range for Ingrezza to be in the mid-teens. So, we feel really good with where the team is positioned.

Speaker #2: And of course, with the Salesforce expansion, going to be in place at the end of Q1, we'd expect to see more benefit in the second half of the

Speaker #2: year. Excellent.

Mohit Bansal: Excellent. Thank you.

Speaker #10: Thank you.

Speaker #3: We'll take our next question from Miles Minter with William Blair. Your line is open.

Operator: We'll take our next question from Miles Minter with William Blair. Your line is open.

Speaker #2: Hey, thanks, guys. I just had a question on the number of Tuesdays in each quarter. I'm actually going to ask about the Salesforce expansion for chronicity onboarding in April.

Myles Minter: Hey, thanks, guys. I just had a question on the number of Tuesdays in each quarter. I'm actually going to ask about the sales force expansion for CRENESSITY onboarding in April. Is that required to keep this steady new patient flow in for the product, or would you expect sometime in the second half of the year, maybe, that that sales force expansion helps inflect the product? Thanks.

Speaker #2: Is that required to keep this steady new patient flow in for the product? Or would you expect sometime in the second half of the year maybe that that Salesforce expansion helps inflect the product?

Speaker #2: Thanks.

Speaker #11: Yeah, the way I would characterize it is

Eric Benevich: Yeah, the way I would characterize it is that we're investing in growth. We're very optimistic about the opportunity with CRENESSITY and classic CAH. We made our sales force size and structure decisions prior to the launch without the sort of, I'll call it, the Monday morning quarterback opportunity of having more data to work with. So obviously, we have been executing this expansion on a relative basis. It's not a large number of FTEs that we're adding into the CRENESSITY team. But we do think it'll allow us to do a couple of things. One is to go deeper within the existing prescriber base. In my prepared remarks, I talked about how we now have over 1,000 doctors that have prescribed CRENESSITY, and yet two-thirds of them have only treated one patient thus far. So we know that there's more patients in those practices.

Speaker #11: That we're investing in growth. We're very optimistic about the opportunity with chronicity and classic CAH. And we made our Salesforce size and structure decisions prior to the launch without the, sort of, I'll call it the Monday morning quarterback opportunity of having more data to work with.

Speaker #11: So obviously, we have been executing this expansion on a relative basis. It's not a large number of FTEs that we're adding into the chronicity team.

Speaker #11: But we do think it'll allow us to do a couple of things. One is to go deeper within the existing prescriber base. And in my prepared remarks, I talked about how we now have over 1,000 doctors that have prescribed Chronicity.

Speaker #11: And yet two-thirds of them have only treated one patient thus far. So we know that there's more patients in those practices. And given the very large territory sizes, this will allow us to get in and follow up with the existing prescribers a little bit more frequently.

Eric Benevich: Given the very large territory sizes, this will allow us to get in and follow up with the existing prescribers a little bit more frequently. Secondly, we also recognize that there are some patients out there that we haven't been able to reach through the existing sales team. So we can go deeper into endocrinology. And we recognize that some patients are not cared for by an endocrinologist. They might be seeing an internal medicine or a family medicine physician or even an OB-GYN. So we have the opportunity now to explore that a little bit with the expanded sales team. Last thing I'll say is that we're excited about the reputation that we've created within the endocrinology community. We're able to attract some really high potential, and I think people with great track records, onto the team. We've actually completed the expansion of that group.

Speaker #11: Secondly, we also recognize that there are some patients out there that we haven't been able to reach through the existing sales team. So we can go deeper into endocrinology and we recognize that some patients are not cared for by an endocrinologist.

Speaker #11: They might be seeing an internal medicine or a family medicine physician, or even have the opportunity now to explore that a little bit with the expanded sales team.

Speaker #11: Last thing I'll say is that we're excited about the reputation that we've created within the endocrinology community. We're able to attract some really high potential and I think people with great track records.

Speaker #11: Onto the team. We've actually completed the expansion of that group. They're going through training now, and they'll be ready to deploy into the new organizational structure at the beginning of Q2.

Eric Benevich: They're going through training now. They'll be ready to deploy into the new organizational structure at the beginning of Q2. So full steam ahead with the expansion, and certainly very excited about the additional bandwidth that we'll have created as we execute against it. So Miles, I'll be holding a webinar about the calendar and how it lays out the rest of the year. Just kidding. But I did want to go back to a question that Phil had regarding CRENESSITY's seasonality. And I think Kyle and Eric addressed it nicely in terms of not having enough experience with CRENESSITY demand side. I meant to mention there is a gross to net impact in the first quarter. It's about 5%, and it's associated with the commercial copay reset. So that's one thing I wanted to make sure as you're developing your models and expectations for Q1 for CRENESSITY.

Speaker #11: So, full steam ahead with the expansion, and certainly very excited about the additional bandwidth that we'll have created as we execute against it.

Speaker #12: So, Miles, I'll be holding a webinar about the calendar and how it lays out the rest of the year. Just kidding. But I did want to go back to a question that Phil had regarding chronicity seasonality.

Speaker #12: And I think Kyle and Eric addressed it nicely in terms of not having enough experience with chronicity on the demand side. I meant to mention there is a gross-to-net impact in the first quarter.

Speaker #12: It's about 5%, and it's associated with the commercial copay reset. So that's one thing I wanted to make sure, as you're developing your models and expectations for Q1, for chronicity.

Speaker #12: That would be something that you take into consideration.

Eric Benevich: That would be something that you take into consideration. Thanks.

Speaker #12: Thanks. We'll move next

Operator: We'll move next to Yigal Nochomovitz with Citigroup. Your line is open.

Speaker #3: To Yugal Nokomovitz with Citigroup, your line is open.

Speaker #3: open. Hi, great.

Yigal Nochomovitz: Hi, Greg. Thank you. And congrats on all the progress. I just wanted to probe a little further on the 10% share in CAH. Is it correct that that's all endos? Are you seeing any early share from some of the other categories you mentioned, like PCPs and OB-GYN? And I'm wondering to what extent at this point you can use some of the AI database inferencing to sort of tease out which PCPs and OB-GYNs may be the best candidates for CRENESSITY.

Speaker #13: Thank you. And congrats on all the progress. I just wanted to probe a little further on the 10% share in CAH. Is it correct that that's all endos?

Speaker #13: Are you seeing any early share from some of the other categories you mentioned, like PCPs and OB/GYN? And I'm wondering, to what extent at this point you can use some of the AI database PCPs and OB/GYNs may be the best inferencing to sort of tease out which candidates for chronicity?

Speaker #2: Yeah. So yeah, I just want to clarify when in my prepared remarks, I talked about the fact that we estimate that we've reached in and gotten onboard treatment approximately 10% of the prevalent CAH population.

Eric Benevich: Yeah. So yeah, I just want to clarify. In my prepared remarks, I talked about the fact that we estimate that we've reached and gotten onboard treatment approximately 10% of the prevalent CAH population. So taking a step back, in the US, we estimate it's around 20,000 people with classic CAH. Obviously, in year one, to get to about 10% of them and get them on treatment is a really important milestone for us. Virtually all of those new patient starts have been originated within endocrinology. We recognize that for us to be able to continue to expand the use of CRENESSITY and get broader within that patient population, we're going to have to be able to reach patients beyond the prescriber base that we've reached thus far. You mentioned patient finding. I talked about that a little bit in my prepared remarks.

Speaker #2: So taking a step back, in the US, we estimate it's around 20,000 people with classic CAH. And obviously, in year one, to get to about 10% of them and get them on treatment, there's a really important milestone for us.

Speaker #2: Virtually all of those new patients starts have been originated within endocrinology. And we recognize that for us to be able to continue to expand the use of chronicity, and get broader within that patient population, we're going to have to be able to reach patients beyond the prescriber base that we've reached thus far.

Speaker #2: And you mentioned patient finding. I talked about that a little bit in my prepared remarks. So we are leveraging different technology platforms in different data sets that will allow us to identify where are patients that look similar at least in the data to the patients that we've already gotten on treatment.

Eric Benevich: So we are leveraging different technology platforms and different datasets that will allow us to identify where are patients that look similar, at least in the data, to the patients that we've already gotten on treatment, and then allow our field sales organization to follow up and to confirm whether those patients exist at this or that practice. Using that information and feeding it back makes the system smarter and allows us to improve our targeting. So this is a rare disease, and there isn't a specific diagnosis code for classic CAH. And so for us to continue to grow and to have that steady growth that we expect, we have to leverage technology, and we also have to leverage the team.

Speaker #2: And then allow our field sales organization to follow up and to confirm whether those patients exist at this or that practice. Using that information and feeding it back makes the system smarter.

Speaker #2: And it allows us to improve our targeting. So this is a rare disease, and there isn't a specific diagnosis code for classic CAH. And so for us to continue to grow and to have that steady growth that we expect, we have to leverage technology.

Speaker #2: And we also have to leverage the

Speaker #2: team. We'll move next to

Operator: We'll move next to David Amsellem with Piper Sandler. Your line is open.

Speaker #3: David Amsalem with Piper Sandler, your line is open.

Speaker #14: Thanks. Maybe I'll ask another chronicity question, but in a different way. As you think about furthering penetration, are you getting any kind of pushback from endocrinologists?

David Amsellem: Thanks. Maybe I'll ask another CRENESSITY question, but a different way. As you think about furthering penetration, are you getting any kind of pushback from endocrinologists? Or maybe I'll ask differently. Are there any barriers to further adoption that you're seeing? And also, as you think about the competitor that's in development, the ACTH antagonist, do you have a sense that doctors are waiting out the availability of that drug to put patients on that modality as opposed to CRENESSITY? Maybe you can talk about that dynamic as well. Thank you.

Speaker #14: Or maybe I'll ask differently. Are there any barriers to further adoption that you're seeing? And also, as you think about the competitor that's in development, the ACTH antagonist, do you have a sense that doctors are waiting out the availability of that drug to put patients on that modality as opposed to chronicity?

Speaker #14: Maybe you can talk about that dynamic as well. Thank you.

Speaker #2: Yeah. Maybe I'll tackle the second question first. The answer is no. I don't think that community endocrinologists are for the most part aware of an investigational drug or are warehousing or holding back treatment of patients for a drug that may or may not be available several years down the road.

Eric Benevich: Yeah, maybe I'll tackle the second question first. The answer is no. I don't think that community endocrinologists are, for the most part, aware of an investigational drug or are warehousing or holding back treatment of patients for a drug that may or may not be available several years down the road. In terms of what's the biggest barrier, I would say it's lack of knowledge. And the reason I say that is that, yes, there are some endocrinologists that are quite familiar with and skilled in managing these patients. But the vast majority of community endocrinologists have little experience with Classic CAH. And if they have CAH patients in their practice, they might have a couple of them.

Speaker #2: In terms of what's the biggest barrier, I would say it's lack of knowledge. And the reason I say that is that, yes, there are some endocrinologists that are quite familiar with and skilled in managing these patients.

Speaker #2: But the vast majority of community endocrinologists have little experience with classic CAH. And if they have CAH patients in their practice, they might have a couple of them.

Speaker #2: And so, a big part of our educational effort—I mentioned this in my prepared remarks—is really continuing to educate around classic CAH, the inadequacies of high-dose glucocorticoid treatments, and the consequences of patients being either over- or undertreated.

Eric Benevich: And so a big part of our educational effort, and I mentioned this in my prepared remarks, is really continuing to educate around classic CAH, the inadequacies of high-dose glucocorticoid treatments, the consequences of patients being either over or undertreated, and then tying that back to the clinical profile that's emerged for CRENESSITY, especially the very strong safety and tolerability that we've seen both in the trials and in the real-world experience. So it's really getting physicians past this sort of, I'll call it, pre-CRENESSITY belief that they're treating their patients with these steroids. They think they're doing fine. But when they look closer, they realize that they're having a lot of comorbidities and a lot of complications from either their disease or from their GCs.

Speaker #2: And then tying that back to the clinical profile that's emerged for chronicity, especially the various strong safety and tolerability that we've seen both in the trials and in the real-world experience.

Speaker #2: So, it's really getting physicians past this sort of—I'll call it—pre-chronicity belief, that they're treating their patients with these steroids. They think they're doing fine.

Speaker #2: But when they look closer, they realize that they're having a lot of comorbidities and a lot of complications from either their disease or from their GCs.

Speaker #2: And as we continue to make education more broad, certainly we're seeing that doctors are realizing that, hey, chronicity is a whole new way of treating CAH.

Eric Benevich: As we continue to make that education more broad, certainly, we're seeing that doctors are realizing that, hey, CRENESSITY is a whole new way of treating CAH. It's a paradigm shift. I think that that's been borne out in the adoption. The other thing that I'll say is that we've been working really closely with the patient advocacy group, the CARES Foundation. They've been a wonderful partner in terms of educating their membership. Certainly, coming into this launch, we recognize that a lot of patients with CAH or families with CAH didn't fully understand the consequences of either uncontrolled androgens and/or excess glucocorticoid exposure. So we continue to direct our educational efforts not just towards HCPs, but also towards the patient community. I think it's really a benefit to both groups.

Speaker #2: It's a paradigm shift. And I think that that's been borne out in the adoption. The other thing that I'll say is that we've been working really closely with the patient advocacy group, the CARES Foundation. They've been a wonderful partner in terms of educating their membership.

Speaker #2: And certainly, coming into this launch, we recognize that a lot of families with CAH didn't fully understand the consequences of either uncontrolled androgens and/or excess glucocorticoid exposure.

Speaker #2: And so we continue to direct our educational efforts not just towards HCPs, but also towards the patient community. And I think it's really a benefit to both groups.

Speaker #3: We'll move next to Brian Scorni with Baird. Your line is open.

Operator: We'll move next to Brian Skorney with Baird. Your line is open.

Speaker #15: Hi, team. Thanks for the question. This is Luke on for Brian. So on chronicity with regard to the remaining estimated 90% untreated prevalent market, can you remind us what proportion is managed at an endocrinologist compared to primary care or other

Eric Benevich: Hi, team. Thanks for the question. This is Luke on for Brian. So on CRENESSITY, with regard to the remaining estimated 90% untreated prevalent market, can you remind us what proportion is managed at an endocrinologist compared to primary care or other settings? Yeah, I think we're learning that. And so it's difficult to give you an exact proportion of what proportion are under the care of an endo versus a PCP. And one of the things that we've seen, at least in the cohort of patients that have been started already on CRENESSITY, is that some of them appear to be co-managed by endocrinologists and primary care. And it may be that they see their endocrinologist once a year, but they may be seeing their primary care physician more frequently. And the question's who's managing their CAH and refilling their prescriptions and so on.

Luke Herrmann: Hi, team. Thanks for the question. This is Luke on for Brian. So on CRENESSITY, with regard to the remaining estimated 90% untreated prevalent market, can you remind us what proportion is managed at an endocrinologist compared to primary care or other settings?

Speaker #15: settings? Yeah.

Eric Benevich: Yeah, I think we're learning that. And so it's difficult to give you an exact proportion of what proportion are under the care of an endo versus a PCP. And one of the things that we've seen, at least in the cohort of patients that have been started already on CRENESSITY, is that some of them appear to be co-managed by endocrinologists and primary care. And it may be that they see their endocrinologist once a year, but they may be seeing their primary care physician more frequently. And the question's who's managing their CAH and refilling their prescriptions and so on.

Speaker #2: I think we're learning that. And so it's difficult to give you an exact proportion of what proportion are under the care of an endo versus a PCP.

Speaker #2: And one of the things that we've seen, at least in the cohort of patients that have been started already on chronicity, is that some of them appear to be co-managed by endocrinologists and primary care.

Speaker #2: And it may be that they see their endocrinologist once a year. But there may be seeing their primary care physician more frequently. And the questions who's managing their CAH and refilling their prescriptions and so on.

Speaker #2: So as we go forward, teasing that out of the data, I think, is really important. And I think that as I mentioned earlier, being able to identify those primary care or OB practices that appear to have multiple CAH patients and having our sales team go in there and follow up, loop that allows us to understand where these patients are and the best way to educate and motivate and activate these

Eric Benevich: So as we go forward, teasing that out of the data, I think, is really important. And I think that, as I mentioned earlier, being able to identify those primary care or OB practices that appear to have multiple CAH patients and having our sales team go in there and follow up, that creates the mechanism or the feedback loop that allows us to understand where these patients are and the best way to educate, motivate, and activate these patients.

Speaker #3: We'll take our next question from Mark Goodman with Lyrinc Partners. Your line is

Operator: We'll take our next question from Mark Goodman with Leerink Partners. Your line is open.

Speaker #3: open. Matt, just a clarification.

Eric Benevich: Matt, just a clarification. You mentioned -4% price spots for 2026. Is that off the 5,500 that was, I think, previously guided for the full year of 2025? And then I just actually have another follow-on on the conversation about ACTH antagonists and just how you guys view that drug to be used eventually, if it ever comes out with everyone, hopefully, on CRENESSITY by then. Is it an add-on? Do you think it'd be a competitive product? Or how do you even view it at that point? Thanks. We haven't disclosed what the net price was for 2025. But you can think about the 4% being year-on-year, more heavily concentrated year-on-year in the first half of this year based upon the timing of when we entered into contracting.

Marc Goodman: Matt, just a clarification. You mentioned -4% price spots for 2026. Is that off the 5,500 that was, I think, previously guided for the full year of 2025? And then I just actually have another follow-on on the conversation about ACTH antagonists and just how you guys view that drug to be used eventually, if it ever comes out with everyone, hopefully, on CRENESSITY by then. Is it an add-on? Do you think it'd be a competitive product? Or how do you even view it at that point? Thanks.

Speaker #16: You mentioned negative 4% price spots for 2026. Is that off the $5,500 that was, I think, previously guided for the full year of '25?

Speaker #16: And then I just actually have another follow-on on the conversation about ACTH antagonist, and just how you guys view that drug to be used eventually if it ever comes out, with everyone hopefully on chronicity by then.

Speaker #16: Is it an add-on? Do you think it'd be a competitive product? Or how do you even view it at that point?

Speaker #16: Thanks. We

Eric Benevich: We haven't disclosed what the net price was for 2025. But you can think about the 4% being year-on-year, more heavily concentrated year-on-year in the first half of this year based upon the timing of when we entered into contracting.

Speaker #2: We haven't disclosed what the net price was for 2025. But you can think about the 4% being year-on-year, more heavily concentrated in the first half of this year, based upon the timing of when we entered into—importantly, and Kyle mentioned this earlier—is that exiting 2025, our net revenue per script is going to be very similar throughout all of 2026.

Eric Benevich: But importantly, and Kyle mentioned this earlier, is that exiting 2025, our net revenue per script is going to be very similar throughout all of 2026. So we did take a bit of a price through 2025 but do expect a lot of stability on the net price side as well as, and most importantly, on the access side to continue to allow us to build this market. And then, Mark, on your competitor question, I've learned a lot over the course of my first full year as CEO. And one of them is how to talk about competition. When it comes to CRENESSITY, we're really talking about two different programs, two different medicines at two different states. CRENESSITY's an approved medicine had a great launch, and we have a multiple-year head start.

Speaker #2: So, we did take a bit of a price through 2025, but do expect a lot of stability on the net price side, as well as—and most importantly—on the access side, to continue to allow us to build this market.

Speaker #15: And then, Mark, on your competitor question, I've learned a lot over the course of my first full year as a CEO, and one of them is how to talk about competition.

Speaker #15: When it comes to chronicity, we're really talking about two different programs, two different medicines at two different states. Chronicity is an approved medicine that's had a great launch.

Speaker #15: And we have a multiple-year head start. I think we've got a medicine that's changing the standard of care across efficacy, safety, tolerability, the formulations, and we're generating a lot of data over time.

Eric Benevich: I think we've got a medicine that's changing the standard of care across efficacy, the safety, tolerability, the formulations. We're generating a lot of data over time. I think it leaves us in a really good position. I think that you all listening on the phone certainly, I've been doing that here, looking at orphan drug launches. I'm really hard-pressed to see any medicine that delivers on the profile of CRENESSITY and is displaced at all by any future medicine. I'm really excited about what we have with CRENESSITY. It's a two-variable positive here for us. We've got a great medicine and a great team that's out there doing great things with prescribers and patients that are there. We're going to focus on building this brand into a great medicine for patients and the company.

Speaker #15: I think it leaves us in a really good position. And I think that you all listening on the phone—certainly, I've been doing that here—looking at orphan drug launches.

Speaker #15: I'm really hard-pressed to see any medicine that delivers on the profile of chronicity and is displaced at all by any future medicine. So I'm really excited about what we have with chronicity.

Speaker #15: It's a two-variable positive here for us. We've got a great medicine and a great team that's out there doing great things with prescribers and patients that are there.

Speaker #15: And we're going to focus on building this brand into a great medicine for patients and the company.

Speaker #3: We'll move next to Akash Tewari with Jefferies. Your line is open.

Operator: We'll move next to Akash Tewari with Jefferies. Your line is open.

Speaker #17: Hi. This is Sibian for Akash. Thank you for taking our question. My question is on chronicity as well. But more so on the pipeline.

Biren Amin: Hi. This is CB on for Akash. Thank you for taking our question. My question is on CRENESSITY as well, but more so on the pipeline. We saw that there's a phase 2 study being initiated for patients under four years old, which we know is not currently on the label. Can you talk about kind of the importance of the study and when we should expect an update here? And could we expect this to be sort of a growth opportunity when and if on market for this population? Thank you.

Operator: Hi. This is CB on for Akash. Thank you for taking our question. My question is on CRENESSITY as well, but more so on the pipeline. We saw that there's a phase 2 study being initiated for patients under four years old, which we know is not currently on the label. Can you talk about kind of the importance of the study and when we should expect an update here? And could we expect this to be sort of a growth opportunity when and if on market for this population? Thank you.

Speaker #17: We saw that there's a phase two study being initiated for patients under four years old, which we know is not currently on the label.

Speaker #17: Can you talk about kind of the importance of the study, and when we should expect an update here? And could we expect this to be sort of a growth opportunity when and if on market for this population?

Speaker #17: Thank you.

Speaker #2: Yes. So, as indicated, we are soon initiating 2032, which is a pediatric study. These are individuals less than four years of age, the youngest age being three months.

Eiry Roberts: Yes. So as indicated, we are soon initiating 2032, which is a pediatric study. These are individuals less than 4 years of age, the youngest age being 3 months. And the intent is to expand our label, which currently is 4 years and above. So again, we're excited about this opportunity. We should have some data next year on that study.

Speaker #2: And the intent is to expand our label which currently is four years and above. So again, we're excited about this opportunity. We should have some data next year on that study.

Speaker #3: We'll move next to Sumant Kulkarni with Canaccord. Your line is open.

Operator: We'll move next to Sumant Kulkarni with Canaccord. Your line is open.

Speaker #18: Good afternoon. Thanks for taking our questions. Bigger picture one here. It looks like you sold your UK and European rare commercial business recently. What does this mean for your plans to develop chronicer font in the UK and the rest of Europe?

Sumant Kulkarni: Good afternoon. Thanks for taking our questions. Bigger picture one here. It looks like you sold your UK and European rare commercial business recently. What does this mean for your plans to develop Crinecerfont in the UK and the rest of Europe? And does that decision mean Neurocrine is going to remain US-focused? And how much did the potential enforcement of Most Favored Nations pricing have to do with that decision?

Speaker #18: And does that decision mean Neurocrine is going to remain US-focused? And how much did the potential enforcement of most-favored-nations pricing have to do with that decision?

Speaker #19: Yeah. This is Kyle. Appreciate the question. I think when it comes to the EU business, the programs that we're working on over there weren't necessarily a good alignment for what we have for our own portfolio today.

Kyle Gano: Yeah, this is Kyle. I appreciate the question. I think when it comes to the EU business, the programs that we're working on over there weren't necessarily a good alignment with what we have for our own portfolio today. So we found a good place for those programs to go with a new team there. In terms of our own interest, obviously, we're focusing on the US market now, making sure that we have a really good launch here with CRENESSITY. And so far, so good there. And we want to keep focusing our attention there and look at ways we can potentially bring CRENESSITY and other future medicines to Europe. Right now, we're not really looking at considerations and variables that play in Most Favored Nation, per se, as much as we are focusing on the US market. But it is an area that is evolving.

Speaker #19: So we found a good place for those programs to go with a new team there. In terms of our own interest, obviously, we're focusing on the US market now, making sure that we have a really good launch here with chronicity.

Speaker #19: And so far, so good there. And we want to keep focusing our attention there and look at ways we can potentially bring chronicity and other future medicines to Europe right now.

Speaker #19: We're not really looking at considerations and variables that play in most favored nation, per se, as much as we are focusing on the US market.

Speaker #19: But it is an area that is evolving. And before we make any decisions definitively, outside the US, we'll want to get clarity on where that's going here in terms of a policy

Kyle Gano: Before we make any decisions definitively outside the US, we'll want to get clarity on where that's going here in terms of a policy standpoint.

Speaker #19: standpoint. We'll take our next question

Operator: We'll take our next question from Sean Laaman with Morgan Stanley. Your line is open.

Speaker #3: from Sean Lamont with Morgan Stanley. Your line is open.

Speaker #3: open.

Speaker #20: Hi, Kyle and team.

Sean Laaman: Hi, Kyle and team. Hope everyone's well. Thanks for taking my question. I have a pipeline question on 890. Just going back to the recent data you showed for INGREZZA and the 80% receptor occupancy, it seems like a pretty high hurdle. So do you think you can beat that with 890? Or is it really with 890 more about just expanding the population base through that long-acting profile?

Speaker #20: Hope everyone's well, and thanks for taking my question. I have a pipeline question on 890. Just going back to the recent data you showed for Ingrezza, the 80% receptor occupancy seems like a pretty high hurdle.

Speaker #20: So do you think you can beat that with 890? Or is it really, with 890, more about just expanding the population breakthrough—that long-acting?

Speaker #20: profile? Yeah.

Eiry Roberts: Yeah, really good question. Because with INGREZZA, as you mentioned, we're actually doing really well from a receptor occupancy point of view. So with respect to 890, we're expecting at least the same receptor occupancy. But to your point, the potential for long-acting injectable formulations, that's because of reduced clearance and also reduced aqueous solubility. So it's a molecule that really is designed to be both oral but administered relatively infrequently. And we think that could capture patients who are not doing so well or not so compliant on their current treatment.

Speaker #2: Really good question, because with Ingrezza, as you mentioned, we're actually doing really well from a receptor occupancy point of view. So, with respect to 890, we're expecting at least the same receptor occupancy.

Speaker #2: But to your point, the potential for long-acting injectable formulations—that's because of reduced clearance and also reduced aqueous solubility. So, it's a molecule that really is designed to be both oral, but administered relatively infrequently.

Speaker #2: And we think that could capture patients who are not doing so well or not so compliant on their current treatment.

Speaker #19: Yeah. Just to add to that, we've certainly looked at that potential with Ingrezza over time. And it's not a well-suited molecule for that as well as other follow-on molecules that we've had over time.

Kyle Gano: Yeah, just to add to that, we've certainly looked at that potential with INGREZZA over time. And it's not a well-suited molecule for that as well as other follow-on molecules that we've had over time. So we're quite excited. But we have with 890 and 675, those are the next-generation VMAT2 inhibitors. And it's taken us a while to get a molecule that actually has a profile that we think is competitive or, if not better, than INGREZZA. So we're excited about getting this phase 2 study up and running and looking to have data sometime towards the end of next year.

Speaker #19: So we're quite excited. But we have with 890 and 675, those are the next generation VMAT2 inhibitors. And it's taken us a while to get a molecule that actually has a profile that we think is competitive or if not better than Ingrezza.

Speaker #19: So we're excited about getting this phase two study up and running. And looking to have data sometime towards the end of next

Speaker #19: year. And we'll take

Operator: We'll take our last question from Danielle Brill with Truist. Your line is open.

Speaker #3: Our last question comes from Danielle Brill with Truist. Your line is open.

Speaker #21: Hi, guys. Good afternoon. Thanks so much for the question. So I know we talked a lot about general barriers to prescribing chronicity and mentioned a few times that two-thirds of your prescribers have only written a single prescription.

[Analyst] (Truist Securities): Hi, guys. Good afternoon. Thanks so much for the question. So I know we talked a lot about general barriers to prescribing CRENESSITY and mentioned a few times that two-thirds of your prescribers have only written a single prescription. I guess I'm just trying to understand what's driving that pattern specifically. How many CAH patients do these physicians typically manage? What feedback are you hearing regarding barriers or hesitations to expand adoption more broadly for these specific prescribers' patient bases at this point? Thank you.

Danielle Brill: Hi, guys. Good afternoon. Thanks so much for the question. So I know we talked a lot about general barriers to prescribing CRENESSITY and mentioned a few times that two-thirds of your prescribers have only written a single prescription. I guess I'm just trying to understand what's driving that pattern specifically. How many CAH patients do these physicians typically manage? What feedback are you hearing regarding barriers or hesitations to expand adoption more broadly for these specific prescribers' patient bases at this point? Thank you.

Speaker #21: I guess I'm just trying to understand what's driving that pattern specifically. How many CAH patients do these physicians typically manage? What feedback are you hearing regarding barriers or hesitations to expand adoption more broadly for these specific prescribers' patient bases at this point?

Speaker #21: Thank

Speaker #21: you. Yeah.

Eric Benevich: Yeah, I think the circumstances are going to be different from physician to physician. But generally speaking, I think the two biggest factors here that are guiding the pace of adoption, especially with those that have written one prescription, is really just the flow of patients into the practice. As I mentioned earlier, a lot of these community endocrinologists that are treating adult patients. They may only see their patient once a year. So that is a factor. And then the second one is, and this is not unique to CRENESSITY. A lot of these physicians also, when they start a patient, they want to see how it does and get some clinical experience. A few months into treatment, typically, is when they would be starting the GC tapering.

Speaker #2: I think the circumstances are going to be different from physician to physician. But generally speaking, I think the two biggest factors here that are guiding the pace of adoption, especially with those that have written one prescription, are really just the flow of patients into the practice.

Speaker #2: As I mentioned earlier, a lot of these community endocrinologists that are treating adult patients, they may only see their patient once a year. So that is a factor.

Speaker #2: And then the second one is, and this is not an unique to chronicity, a lot of these physicians also, when they start a patient, they want to see how it does.

Speaker #2: And get some clinical experience, a few months into treatment typically is when they would be starting the GC tapering. And anecdotally, what I'm hearing is that many of them are taking it easy in terms of just slowly bringing down the GC doses.

Eric Benevich: Anecdotally, what I'm hearing is that many of them are taking it easy in terms of just slowly bringing down the GC doses. So it's not sort of a forced down titration. So I think those two factors together kind of get at what might be inhibiting some of these doctors from getting their second or their third patient on treatment. But like I mentioned earlier, most community adult endocrinologists, if they have classic CAH in their practice, only have a few patients. So this is a market that has a small number of what I'd call KOLs or experts, and then a large number out in the community that have very few patients. And so it's an inch deep and a mile wide, so to speak. But in order for us to really optimize this opportunity, we have to reach and educate everyone. And that's what we're doing.

Speaker #2: So it's not sort of a forced down titration. So I think those two factors together kind of get at what is keeping these doctors from getting their second or their third. That might be inhibiting some patients on treatment.

Speaker #2: But like I mentioned earlier, most community adult endocrinologists, if they have classic CH in their practice, only have a few patients. So this is a market that is has a small number of what I'd call KOLs or experts.

Speaker #2: And then a large number out in the community that have very few patients. And so it's an inch deep and a mile wide, so to speak.

Speaker #2: But in order for us to really optimize this opportunity, we have to reach and educate everyone, and that's what we're doing. And, obviously, we're very pleased with the first year.

Eric Benevich: Obviously, we're very pleased with the first year. We expect to have a lot of success in 2026 and beyond.

Speaker #2: And we expect to have a lot of success in 2026 and beyond.

Speaker #3: Thank you. That does end the Q&A session for today's call. I would now like to hand the call back to Kyle for any additional or closing remarks.

Operator: Thank you. That does end the Q&A session for today's call. I would now like to hand the call back to Kyle for any additional or closing remarks.

Speaker #2: Thanks, Gloria. I want to thank you all for joining today and for the constructive discussion. During the call, we shared updates on our commercial performance and development programs as well as the outlook for the business.

Kyle Gano: Thanks, Gly. I want to thank you all for joining today and for the constructive discussion. During the call, we shared updates on our commercial performance and development programs as well as the outlook for the business. I want to be clear. Our focus remains on disciplined execution as we think about 2026, which means a couple of things: driving revenue growth and diversification with INGREZZA and CRENESSITY, advancing the pipeline in the process of delivering meaningful long and in this process, delivering meaningful long-term value for patients and shareholders. We've got a lot of momentum that we're building this year for a data-rich 2027. And that's just going to be the tip of the iceberg. The way that the pipeline's set up will deliver a constant flow of data starting from 2027 and in future years.

Speaker #2: I want to be clear, our focus remains on disciplined execution as we think about 2026, which means a couple of things: driving revenue growth and diversification with Ingrezza and chronicity.

Speaker #2: Advancing the pipeline and the process of delivering meaningful long and in this process, delivering meaningful long-term value for patients and shareholders. We've got a lot of momentum that we're building this year.

Speaker #2: For data-rich 2027. And that's just going to be the tip of the iceberg. The way that the pipeline is set up will deliver a constant flow of data starting from 2027 and in future years.

Speaker #2: So in close, please don't hesitate to reach out on any of the topics that we discussed today. We look forward to continuing the dialogue with and meeting with many of you as we progress throughout the year.

Kyle Gano: So in closing, please don't hesitate to reach out on any of the topics that we discussed today. We look forward to continuing the dialogue and meeting with many of you as we progress throughout the year. So thanks again. And talk to you soon.

Speaker #2: So thanks again. And talk to you soon.

Operator: Thank you. This brings us to the end of today's meeting. We appreciate your time and participation. You may now disconnect.

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